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KMID : 1140220170220020074
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대한암예방학회지
2017 Volume.22 No. 2 p.74 ~ p.81
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Genomic Profiling of Chronic Myelogenous Leukemia: Basic and Clinical Approach
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Keramatinia Aliasghar
Ahadi Alireza
Akbari Mohammad Esmaeil
Mohseny Maryam
Jarahi Alireza Mosavi
Mehrvar Narjes
Mansouri Neda
Tabatabaei S.A. Mortazavi
Movafagh Abolfazl
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Abstract
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Chronic myeloid leukemia (CML) is a hematological stem cell cancer driven by BCR-ABL1 fusion protein. We review the previous and recent evidence on the significance of CML in diagnostic and clinic management. The technical monitoring of BCR-ABL1 with quantitative real time-PCR has been used in assessing patient outcome. The cytogenetic mark of CML is Philadelphia chromosome, that is formed by reciprocal chromosomal translocations between human chromosome 9 and 22, t(9:22) (q34:q11). It makes a BCR-ABL1 fusion protein with an anomaly tyrosine kinase activity that promotes the characteristic proliferation of progenitor cells in CML and acute lymphoblastic lymphoma. The targeting of BCR-ABL1 fusion kinase is the first novel paradigm of molecularly targeted curing.
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KEYWORD
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Chronic myeloid leukemia, Profile, Methods, BCR-ABL1
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